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HOW TO USE: This medication is for use on the skin only. Silver sulfadiazine belongs to a class of drugs known as sulfa antibiotics.Silver sulfadiazine must not be used on premature babies or on newborns during the first 2 months of life because of the risk of serious side effects. This helps to decrease the risk of the bacteria spreading to surrounding skin, or to the blood where it can cause a serious blood infection (sepsis). Silver sulfadiazine works by stopping the growth of bacteria that may infect an open wound. USES: This medication is used with other treatments to help prevent and treat wound infections in patients with serious burns. Not recommended for use in pregnant women unless the burned area covers more than 20% of body surface or therapeutic benefits to patient outweigh the possible risks to the fetusĪlthough silver sulfadiazine is minimally absorbed, it reacts with body fluids to release sulfadiazine, which is absorbed and may reach substantial serum concentrationsĪbsorption of silver sulfadiazine varies depending on the percent of body surface area and the extent of the tissue damage it is possible that any adverse reaction associated with sulfonamides may occur including blood dyscrasias, dermatologic and allergic reactions (including life-threatening cutaneous reactions ), GI reactions, hepatitis and hepatocellular necrosis, CNS reactions, and toxic nephrosisįor topical use only avoid contact with eye Prolonged use may result in bacterial or fungal superinfection Use caution in G6PD deficiency hemolysis may occurįor topical use only avoid contact with eyes Pregnant women at term or near term premature infants, or in infants 2 months or younger Cautions Minor (1)trypsin decreases effects of silver sulfadiazine by pharmacodynamic antagonism. Use Caution/Monitor.Ĭomment: Heavy metal ions inactivate enzymes. Monitor Closely (1)silver sulfadiazine decreases effects of trypsin by Other (see comment). Minor (1)papain decreases effects of silver sulfadiazine by pharmacodynamic antagonism. Monitor Closely (1)silver sulfadiazine decreases effects of papain by Other (see comment). Minor (1)collagenase decreases effects of silver sulfadiazine by pharmacodynamic antagonism. Monitor Closely (1)silver sulfadiazine decreases effects of collagenase by Other (see comment). Serious - Use Alternative (1)silver sulfadiazine decreases effects of allogeneic cultured keratinocytes and fibroblasts by Other (see comment). Trypsin decreases effects of silver sulfadiazine by pharmacodynamic antagonism.
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Papain decreases effects of silver sulfadiazine by pharmacodynamic antagonism. Use Caution/Monitor.Ĭollagenase decreases effects of silver sulfadiazine by pharmacodynamic antagonism. Silver sulfadiazine decreases effects of trypsin by Other (see comment). Silver sulfadiazine decreases effects of papain by Other (see comment).
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Silver sulfadiazine decreases effects of collagenase by Other (see comment). Avoid or Use Alternate Drug.Ĭomment: Silver-containing antimicrobials and dressings may decrease viability of keratinocytes and human dermal fibroblasts. Silver sulfadiazine decreases effects of allogeneic cultured keratinocytes and fibroblasts by Other (see comment).